As it soothes, disinfects, and astringes the mucous membranes, Balm of Gilead is an excellent remedy for sore throats, coughs and laryngitis. It may be used in chronic bronchitis. Externally it can be used to ease inflammations due to rheumatism and arthritis, as well as for dry and scaly skin conditions such as psoriasis and dry eczema.Place infusion of leaves in bath water for invigorating bath, crush leaves in hand to clear head, rub leaves on skin to repel mosquitoes. Said to be an aphrodisiac when applied to certain areas of the body.

King's Dispensatory says that "Poplar buds are reputed stimulant, tonic, diuretic, and anti-scorbutic. A tincture has been beneficially employed in affections of the chest, stomach, and kidneys and in rheumatism and scurvy. With oil they form a useful external application in bruises, swellings, wounds, some cutaneous diseases, rheumatic pains."